Possible Protective Effects of Stem Cells Treatment on Ischemic/Reperfused Hearts in Hypertensive Rats Model

Abstract Back Ground Hypertension and its cardiovascular complications as myocardial infarction are the leading causes of morbidity mortality worldwide. Reperfusion strategies current standard therapy but they result in cardiac ischemia reperfusion injury. Stem cell transplantation has emerged a promising therapeutic strategy showed many beneficial effects different medical disorders reno-vascular hypertension. Aim Work To assess possible protective bone marrow derived mesemchymal stem cells treatment on ischemic/reperfused hearts hypertensive rats. Materials & Methods 49 adult female Wistar albino rats, were allocated into three main groups: control group, untreated (Ht-u) group (Ht-SCs) treated group. Body weight, arterial blood pressure, ECG recording, isolated heart study with exposure to injury fluorescence imaging labeled MSCs heart, aorta liver performed. Plasma lipid profile, nitric oxide, MDA SOD levels estimated. Cardiac tissues weighed. Heart, histopathologically assessed. Results Ht-SCs demonstrated significant increase body weight gain %, decrease R voltage, SBP, DBP MAP sixth week values compared HT-u showing non-significance from control. Significant rate basal all non-significant PT/LVW detected Basal TPT HRT significantly shortened MFR/LVW was increased than being non-significantly changed denoting systolic diastolic function improvement.TPT prolongation after IR lower HT-SC This accompanied by atherogenic index, plasma nitrites, SOD. BM-MScs aortic tissues. Conclusion Single injection exerted anti-hypertensive anti-hypertrophic effects, reduced dysfunction improved coronary flow through homing mitigating endothelial exerting angiogenic anti-oxidant, anti-inflammatory anti-apoptotic effects.